Pegasus provides a great filter control mechanism for you to automatically process incoming emails. You can create rules to do a lot of things: send prepared e-mail replies based on keywords in the subject line; let the client side software sound when urgent emails arrive; and automatically create "I'm not here" reply messages for different email senders.
Using Pegasus Mail, you obviously feel that its interface is different: all the icons are the old style, and you have to try to understand the functions of the icons yourself. This is the biggest drawback of Pegasus Mail.